【プレスリリース】わずか60秒で巨大DNAのサイズ分析を実現

Lab on a Chip, 2025 in press

https://www.nagoya-u.ac.jp/researchinfo/result/2025/07/60dna.html

・ナノスリット流路による巨大DNAのサイズ分析法を開発し、既存技術よりも高分離能 ・短時間でサイズ分析を実現。

・DNAの緩和時間（伸長状態からコイル状へ戻るまでの時間）を計測することで、サイズを正確に判別。

・デバイスは簡便なフォトリソグラフィで製造可能、わずか200分子で解析可能なため、量産・実用化に向けた展開が期待。

・新手法により、高精度かつ網羅的な疫学解析が可能、薬剤耐性菌対策への貢献が期待｡

雑誌名：Lab on a Chip

論文タイトル：Size analysis of large DNA molecules by relaxation time measurement using a nanoslit channel

著者：Hongdong Yi, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang, Naoki Azuma

DOI: 10.1039/D4LC00998C

URL: https://pubs.rsc.org/en/content/articlelanding/2025/lc/d4lc00998c

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https://www.nagoya-u.ac.jp/researchinfo/result/2025/07/60dna.html

• A method for analyzing the size of giant DNA using nano-slit flow channels has been developed, enabling higher separation efficiency than existing technologies and size analysis in a short time.

• The size can be accurately determined by measuring the relaxation time (the time it takes for the DNA to return from an extended state to a coiled state).

• The device can be manufactured using simple photolithography and can analyze as few as 200 molecules, so it is expected to be developed for mass production and practical application.

• The new method enables high-precision and comprehensive epidemiological analysis, contributing to strategies against drug-resistant bacteria.

Journal: Lab on a Chip

Title: Size analysis of large DNA molecules by relaxation time measurement using a nanoslit channel

Authors: Hongdong Yi, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang, Naoki Azuma

DOI: 10.1039/D4LC00998C

URL: https://pubs.rsc.org/en/content/articlelanding/2025/lc/d4lc00998c

分野融合研究優秀表彰を受賞

ROBOMECH2024

ROBOMECH2024で発表した以下の研究発表が分野融合研究優秀表彰を受賞しました．発表者の長野圭造君（M2）は日本機械学会 若手優秀講演フェロー賞を同時に受賞しました．おめでとう！

• "ポリマーブラシ膜のパターニングを⽤いた界⾯制御によるマイクロ電気泳動チップの開発", 長野圭造，伊藤伸太郎，福澤健二，東直輝，張賀東

  
  

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The following research presentation made at ROBOMECH2024 has been awarded the Outstanding Interdisciplinary Research Award. The presenter, Keizo Nagano (M2), also received the Japan Society of Mechanical Engineers Young Excellent Speaker Award. Congratulations!

• “Development of a microelectrophoresis chip using interface control by patterning polymer brush films,” Keizo Nagano, Shintaro Ito, Kenji Fukuzawa, Naoki Azuma, and Hedong Zhang

トライボロジー会議2025春で学会発表

トライボロジー会議2025春

日本トライボロジー学会主催のトライボロジー会議2025春で学会発表しました．主な研究発表は以下の通りです．

• "浮遊ポリマーの分子量が水和ポリマー ブラシ膜の摩擦・摩耗特性に与える影響", 横井颯人，伊藤伸太郎，西川智章，野呂篤史 ，梶田貴都，福澤健二，東直輝，張賀東

• "吸着膜厚の直接測定による高分子添加剤ポリアルキルメタクリレートの吸着エネルギ ーの定量化", 黒田雅也，田辺翔矢，SongYuxi，福澤健二，伊藤伸太郎，東直輝，張賀東

• "ポリアルキルメタクリレート(PAMA)系高分子 添加剤の濃度が吸着膜の構造とトライボロ ジー特性に及ぼす影響", ソンユシ，福澤健二，伊藤伸太郎，張賀東，東直輝

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We presented our research at the Tribology Conference 2025 Spring hosted by the Japan Society of Tribologists. The main research presentations are as follows.

• “Effect of molecular weight of suspended polymers on friction and wear properties of hydrated polymer brush films,” Hayato Yokoi, Shintaro Itoh, Tomoaki Nishikawa, Atsushi Noro, Takato Kajita, Kenji Fukuzawa, Naoki Azuma, Hedong Zhang

• “Quantification of adsorption energy of polymer additive polyalkyl methacrylate by direct measurement of adsorption film thickness,” Masaya Kuroda, Shoya Tanabe, Song Yuxi, Kenji Fukuzawa, Shintaro Itoh, Naoki Azuma, Hedong Zhang

• “Effect of polyalkyl methacrylate (PAMA) polymer additive concentration on the structure and tribological properties of adsorption films,” Song Yuxi, Fukuzawa Kenji, Shintaro Itoh, Hedong Zhang, Naoki Azuma